Abemaciclib D7

Product Name Abemaciclib D7
Alternate Names Abemaciclib Stable Isotopes, Stable Isotopes of Abemaciclib
CAT No. CS-O-32772
CAS No. 1231929-97-7 (Unlabeled)
Category Stable Isotopes
Stock Enquire
Mol. Wt. 513.64 g/mol
Mol. For. C27H25D7F2N8
Hazardous This is not a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Parent API Abemaciclib
Therapeutic Anti-Cancer / Oncology
Canonical Smiles CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F
InchIKey UZWDCWONPYILKI-UHFFFAOYSA-N
Inchl InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)
IUPAC N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine
Controlled No
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What is the usage and chemical information of Abemaciclib D7 ?


Abemaciclib D7 is a deuterated version of Abemaciclib, which is a selective inhibitor of cyclin-dependent kinases (CDK) 4 and 6. It is used for the treatment of metastatic breast cancer that is hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-). The chemical formula of Abemaciclib D7 is C27H32D7N8O2, and its molecular weight is 471.67 g/mol. The deuterated form of Abemaciclib has seven deuterium atoms substituted for hydrogen atoms, which makes it useful for pharmacokinetic and pharmacodynamic studies. Abemaciclib D7 works by inhibiting the activity of CDK4 and CDK6 enzymes, which are involved in the regulation of the cell cycle. By blocking these enzymes, Abemaciclib D7 can slow down the growth and division of cancer cells, thereby reducing the size of tumors. The recommended dosage of Abemaciclib D7 is 150 mg twice daily, with or without food. It is usually taken in combination with other medications such as aromatase inhibitors or fulvestrant. Common side effects of Abemaciclib D7 include fatigue, nausea, diarrhea, decreased appetite, and infections. In conclusion, Abemaciclib D7 is a deuterated version of Abemaciclib that is used for the treatment of metastatic breast cancer. It works by inhibiting CDK4 and CDK6 enzymes, and its chemical structure makes it useful for pharmacokinetic and pharmacodynamic studies.

Related Compounds

Abemaciclib Impurity 1 D12 | Abemaciclib D5 | Abemaciclib D8 | Abemaciclib Impurity 5 D5 | Abemaciclib D10 | Abemaciclib Impurity 1 D5 |

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