Bivalirudin-(D-Phe-12)
| Product Name | Bivalirudin-(D-Phe-12) |
|---|---|
| Alternate Names | Bivalirudin Impurities, Impurities of Bivalirudin |
| CAT No. | CS-O-14542 |
| CAS No. | Not Available |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 2180.29.60.05 g/mol |
| Mol. For. | C₉₈H₁₃₈N₂₄O₃₃•C₂HF₃O₂ |
| Hazardous | This is not a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Bivalirudin |
| Therapeutic | Synthetic Peptides |
| Smileys | O=C(N(CCC1)[C@@H]1C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC2=CC=C(O)C=C2)=O)=O)=O)[C@@]([C@@H](C)CC)([H])NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](NC([C@H](CC(O)=O)NC(CNC([C@H](CC(N)=O)NC(CNC(CNC(CNC(CNC([C@H](CCC3)N3C([C@H](CCCNC(N)=N)NC([C@H](CCC4)N4C([C@H](N)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O.OC(C(F)(F)F)=O |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Bivalirudin-(D-Phe-12) is a synthetic peptide consisting of 20 amino acids that is used as an anticoagulant drug. It is a direct thrombin inhibitor that works by binding to the active site of thrombin, thus preventing the formation of fibrin clots. Bivalirudin-(D-Phe-12) is used in patients undergoing percutaneous coronary intervention (PCI) and in those with heparin-induced thrombocytopenia (HIT). It is administered intravenously and has a short half-life of approximately 25 minutes.
Bivalirudin-(D-Phe-12) is a modified version of hirudin, a natural anticoagulant found in the saliva of leeches. The modification involves the substitution of phenylalanine at position 12 with D-phenylalanine, which increases the drug's stability and potency. Bivalirudin-(D-Phe-12) also has a lower risk of bleeding compared to other anticoagulants, such as unfractionated heparin.
The chemical structure of Bivalirudin-(D-Phe-12) is as follows: H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH. It has a molecular weight of 2180.3 g/mol and a pKa value of 4.5. Bivalirudin-(D-Phe-12) is soluble in water and has a pH range of 5.0-7.5.
In summary, Bivalirudin-(D-Phe-12) is a potent direct thrombin inhibitor that is used as an anticoagulant in patients undergoing PCI and in those with HIT. Its modified structure increases its stability and potency while also lowering the risk of bleeding.
Get an Instant Quote
Related Compounds
Bivalirudin Des-Gly Fragment Trifluoroacetic Acid Salt | Bivalirudin Plus-Gly Fragment Trifluoroacetic Acid Salt | bivalirudin [12-20] fragment | Bivalirudin Impurity 3 (Bivalirudin D-Asn Impurity) | beta-Asp9 | Bivalirudin Impurity ([β-Asp9]-Bivalirudin) | Bivalirudin Des-Gly Fragment | Bivalirudin Impurity 1 | Bivalirudin Plus-Gly Fragment | alfa-Asp9 | des-(Glu13)-Bivalirudin | Bivalirudin β-ASPA 9 Analog Trifluoroacetic Acid Salt | des-Glu13 Bivalirudin(Secondary Standards traceble to USP) | Bivalirudin 1-11 Fragment Trifluoroacetic Acid Salt | Bivalirudin α-ASPA 9 Analog Trifluoroacetic Acid Salt | Bivalirudin 12-20 Fragment Trifluoroacetic Acid Sal | D-Phe12 - bivalirudin |